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The influence of pyroptosis on TME.After being released into TME, IL-1β escalates the maturation of dendritic cells (DCs), activates antigen-specific cytotoxic CD8+ T cells, recruits Th1 CD4+ T cells, but suppresses the differentiation of immunosuppressive Treg cells. IL-18 polarizes Th1 cells, recruits and activates natural killer (NK) cells, and produces adhesion molecules, chemokine, and nitric oxide.
