TABLE 3.
Secondary outcomes of the meta-analysis (categorical variables).
| COP group events/patients | TCC group events/patients | |
| Prosthesis pop-out | ||
| Pascual et al. (22) | 1/161 | 3/161 |
| Mendiz et al. (23) | 1/156 | 0/101 |
| Raza et al. (20) | 0/46 | 0/17 |
| Heterogeneity: χ2 = 1.36, df = 1 (p = 0.244), I2 = 26.3%. Fixed-effects model, OR: 0.602, 95% CI: 0.113–3.206, p = 0.584. | ||
| Second valve implantation | ||
| Doldi et al. (21) | 1/61 | 0/61 |
| Pascual et al. (22) | 5/161 | 5/161 |
| Raza et al. (20) | 2/46 | 0/17 |
| Heterogeneity: χ2 = 0.50, df = 2 (p = 0.779), I2 = 0%. Fixed-effects model, OR: 1.276, 95% CI: 0.437–3.722, p = 0.655. | ||
| Mortality | ||
| Doldi et al. (21) | 0/61 | 1/61 |
| Pascual et al. (22) | 4/161 | 4/161 |
| Mendiz et al. (23) | 4/156 | 5/101 |
| Goel et al. (17) | 3/202 | 8/325 |
| Raza et al. (20) | 3/46 | 0/17 |
| Heterogeneity: χ2 = 1.57, df = 4 (p = 0.815), I2 = 0%. Fixed-effects model, OR: 0.714, 95% CI: 0.350–1.458, p = 0.356. | ||
| Stroke | ||
| Doldi et al. (21) | 2/61 | 3/61 |
| Pascual et al. (22) | 9/161 | 9/161 |
| Mendiz et al. (23) | 1/156 | 0/101 |
| Raza et al. (20) | 1/46 | 1/17 |
| Heterogeneity: χ2 = 0.80, df = 3 (p = 0.849), I2 = 0%. Fixed-effects model, OR: 0.900, 95% CI: 0.414–1.955, p = 0.790. | ||
| New-onset LBBB | ||
| Doldi et al. (21) | 29/61 | 27/61 |
| Pascual et al. (22) | 33/161 | 27/161 |
| Mendiz et al. (23) | 9/156 | 13/101 |
| Goel et al. (17) | 24/202 | 47/325 |
| Heterogeneity: χ2 = 5.16, df = 3 (p = 0.160), I2 = 41.9%. Fixed-effects model, OR: 0.913, 95% CI: 0.668–1.249, p = 0.569. | ||
| Moderate or more paravalvular leakage | ||
| Doldi et al. (21) | 3/61 | 1/61 |
| Pascual et al. (22) | 6/161 | 7/161 |
| Mendiz et al. (23) | 4/156 | 2/101 |
| sadiq et al. (14) | 7/75 | 5/104 |
| Raza et al. (20) | 1/46 | 1/17 |
| Heterogeneity: χ2 = 2.47, df = 4 (p = 0.651), I2 = 0%. Fixed-effects model, OR: 1.310, 95% CI: 0.673–2.549, p = 0.426. |
The abbreviation and application of the random- or fixed-effects model were the same as in Table 2. The pooled analysis of post-operative outcomes included studies that reported in-hospital or 30-day outcomes.