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Recruitment of tumor-associated neutrophils (TANs) to primary tumors. Neutrophils from circulation and resident cells within the tumor microenvironment (TME) are recruited by cytokines, growth factors, and chemokines, such as IL-8 and CXCL2. Tyrosine kinase discoid domain receptor 1 (DDR1) is a key regulator of tumor cell metastasis. DDR1 activation by collagen in cancer cells is a significant stimulus for the synthesis of CXCL5, leading to the recruitment of TANs to primary tumors.
