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. 2022 Aug 17;13:904448. doi: 10.3389/fphar.2022.904448

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Copyright © 2022 Wei, Chao-yang, Wen-ming, Ze-yuan, Yong-qiang, Shun-bai, Kai, Yan-chao and Hai-hong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Different immune microenvironment and immune-related functions in the osteosarcoma subtypes. (A) The value of the nonnegative matrix factorization (NMF). (B) The NMF clustering-based value of best cophenetic. (C) Kaplan–Meier curves of OS in the three clusters. (D–F) The ESTIMATE score, stromal score, and immune score of OS subtypes. (G) The percentage of immune cells in the three clusters. (H) The significant immune-related functions in the three clusters.