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. 2022 Aug 17;13:947785. doi: 10.3389/fphar.2022.947785

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Copyright © 2022 Zhao, Cheng, Piao, Cui and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NAc dopamine receptors in D1-MSNs and D2-MSNs receive PFC glutamatergic and GABAergic inputs, and VTA dopaminergic and GABAergic inputs. The direct NAc innervation of the VTA/SNr is mainly mediated by D1-MSNs. In general, NAc core projects to dlVP, NAc shell innervates the vmVP, and this process is mainly mediated by D2-MSNs.Whereas D1-MSNs mediate reinforcement and reward or antidepressant-like behavior, D2-MSNs have been associated with punishment and aversion or depressant-like behavior. VTA, ventral tegmental area; SNr, substantia nigra pars reticulata; VP, ventral pallidum; dlVP, dorsolateral pallidum; vmVP, ventromedial pallidum.