FIGURE 2.

Opportunities for ferroptosis in glioblastoma therapy. Contribution of natural compounds to the treatment of glioblastoma such as dihydroartemisinin, curcumin, pseudolaric acid B and amentoflavone. The upper box shows the chemical structures of these four compounds and the associated mechanisms that regulate ferroptosis in glioblastoma. The below box lists the potential advantages of nanomedicine in the diagnosis and therapy of glioblastoma. ATF4, activating transcription factor 4; ER, endoplasmic reticulum; FTH, ferritin heavy chain. GPX4, glutathione peroxidase 4; HSPA5, heat shock protein family A (Hsp70) member 5; NOX4, NADPH oxidase 4; PERK, protein kinase R-like ER kinase; xCT, SLC7A11, solute carrier family 7 member 11.