FIGURE 4.

Signal pathways, transcription factors and ncRNAs that regulate glycolysis in osteosarcoma. The enhancement of glycolysis in osteosarcoma promotes the malignant behaviors such as proliferation, metastasis and drug resistance of osteosarcoma cells. Most miRNAs inhibit the progression of osteosarcoma by inhibiting glycolysis, with the exception of miR-21-5p and miR-522-3p. Most lncRNAs promotes the progression of osteosarcoma by promoting glycolysis, with the exception of lncRNA-SARCC and lncRNAHAND2-AS1. All circRNAs promote osteosarcoma progression by promoting glycolysis. Transcription factors c-myc and HIF-1α promote glycolysis and osteosarcoma progression. Signal pathways PI3K/AKT, AKT/mTOR, NF-κB, TGF-β, EGFR, Wnt/β-catenin, Wnt5a/Ror2 promote glycolysis pathway and osteosarcoma progression.