Figure 2.

Schematic diagram depicting domains of Lysine acetyl transferases modulating androgen receptor. (A) Schematic diagram of lysine acetyl transferases (KATs) depicting their domain organization that interact and modulate androgen receptor activity. (B) Amino acids acetylated by different KAT proteins in AR p300/CBP, PCAF and TIP60 acetylate lysine residues 630, 632 and 633 while GCN5 acetylate lysine residue 630 situated within hinge domain, while ARD1 acetylate lysine 618 located in DBD region. Sites targeted for acetylation by HBO1 and MOF are still not been identified.