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. 2022 Aug 17;9:963598. doi: 10.3389/fnut.2022.963598

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Copyright © 2022 Jiang, Wang, Chen, Duan, Sun, Huang, Peng, Yu, Wang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of PCP-1C on oxidative stress and apoptosis in ALD mice. (A) Hepatic SOD levels. The serum levels of (B) MDA, (C) GSH-Px, (D) Nrf2, and (E) HO-1. (F) Representative immunoblot images of CYP2E1 and related proteins are involved in the apoptosis pathway in liver tissues. (G) Relative protein levels of CYP2E1 and related proteins involved in the apoptosis pathway. (H–J) Immunohistochemical staining of Bax and Bcl-2 in liver tissue. The results are presented as mean ± SD. *P < 0.05, ^**P < 0.01, ^***P < 0.001 vs. control group; ^#P < 0.05, ^##P < 0.05, ^###P < 0.001 vs. model group. ^&P < 0.05, ^&⁣&P < 0.01, ^&⁣&⁣&P < 0.001 represents significance between PCP-1C groups.