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. 2022 Aug 17;13:945609. doi: 10.3389/fendo.2022.945609

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Copyright © 2022 Xing, Zhao, Zhang and He

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in metabolic parameters after MET and COM therapy. (A) Changes in FG after MET and COM therapy. (B) Changes in FINS after MET and COM therapy. (C) Changes in HOMA-IR after MET and COM therapy. (D) Changes in AUCglu after MET and COM therapy. (E) Changes in AUCins after MET and COM therapy. (F) Changes in AUCglu/AUCins after MET and COM therapy. (G) Changes in OGTT (glucose) after MET and COM therapy. (H) Changes in OGTT (insulin) after MET and COM therapy. MET, metformin; COM, combine; FG, fasting glucose; FINS, fasting insulin; HOMA-IR, homeostasis model assessment-insulin resistance; AUCglu, area under the curve (AUC) for glucose; AUCins, AUC for insulin. Results are expressed as mean ± SD; ^* P < 0.05, ^** P < 0.01 (vs. before treatment in each group).