Supplementary Fig. S2.

a, Densitometry quantification of p-MLKL b, PGC-1α, c, SRX, d, PRX3, and e, hyperoxidized forms of PRX1, PRX2 and PRX3, vs. β-tubulin protein levels analyzed by western-blot in pancreas from wild-type (WT) and p53 knockout (KO) mice under basal conditions (sham) and with acute pancreatitis at 24 h after the first cerulein injection. Data are normalized to data of wild-type sham mice and presented as mean ± SD, **P < 0.005, *P < 0.05 (two-way ANOVA, followed by Tukey's multiple comparisons test). f, Mitochondrial H₂O₂ generation in pancreatic isolated mitochondria from wild-type mice under basal conditions (sham) and with acute pancreatitis at 24 h after the first cerulein injection. g, Superoxide levels measured in pancreatic isolated mitochondria from wild-type mice under basal conditions (sham) and with acute pancreatitis at 24 h after the first cerulein injection. Data are presented in panels f and g as mean ± SD, **P < 0.005, *P < 0.05 (t-test sham vs. cerulein at 24 h).