Supplementary Fig. S3.

a, Densitometry quantification of p-MLKL, b, hyperoxidized forms of PRX1/2, c, hyperoxidized form of PRX3, and d, p53 vs. β-tubulin protein levels analyzed by western-blot in pancreas from wild-type (WT) and SRX knockout (KO) mice under basal conditions (sham) and with acute pancreatitis at 7 h after the first cerulein injection. e, Densitometry quantification of p53 vs. TOM20 protein levels analyzed by western-blot in mitochondrial fraction of pancreas from wild-type (WT) and SRX knockout (KO) mice under basal conditions (sham) and with acute pancreatitis at 7 h after the first cerulein injection. Data in panels a, b, c, d, and e, are normalized to data of wild-type sham mice and presented as mean ± SD, **P < 0.005, *P < 0.05 (two-way ANOVA, followed by Tukey's multiple comparisons test). f, Densitometry quantification of p53 vs. TOM20 protein levels analyzed by western-blot in mitochondrial fraction of pancreas from SRX KO mice under basal conditions (sham), with acute pancreatitis at 7 h after the first injection of cerulein, and with acute pancreatitis and mito-TEMPO treatment. g, Densitometry quantification of p-MLKL vs. β-tubulin protein levels analyzed by western-blot in pancreas from from wild-type (WT) and SRX knockout (KO) mice under basal conditions (sham) and with acute pancreatitis at 7 h after the first cerulein injection. Data in panels f and g, are normalized to data of SRX KO sham mice and presented as mean ± SD, **P < 0.005, *P < 0.05 (one-way ANOVA, followed by Tukey's multiple comparisons test).