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. 2022 Aug 19;20:4549–4561. doi: 10.1016/j.csbj.2022.08.037

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© 2022 Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Condition-specific transcriptome alterations. (a) tSNE visualization of the pooled samples as colored by region (left) and condition (right). (b) A heatmap of differentially expressed genes across neurodegenerative disorders (ND) and neuropsychiatric disorders (NP). The row labels represent the genes differentially expressed in at least 5 conditions. (FDR-corrected P < 0.05 & |log2FC| > 0.58). (c) Conditions-specific gene enrichment analysis. Top significantly enriched pathways are represented for significantly differentially expressed genes across conditions (FDR-corrected p-value < 0.05).