Table 1.
Biochemical Parameters of patients referred with pediatric acute liver failure
| Variable | Medians and IQR | ||||||
|---|---|---|---|---|---|---|---|
| Total N = 45 |
Recovered (n = 6) |
Died or transplanted (n = 39) | P valuea | Transplanted patients (n = 20) |
Died before transplant (n = 19) | P valueb | |
| Peak INR | 7.2 (4.5–10.0) | 3.7 (2.2–4.7) | 7.6 (4.7–10.0) | 0.030 | 7 (3.9–10.0) | 7.8 (5.3–10.0) | 0.078 |
| Fibrinogen (g/L) | 1.1 (1.0–1.4) | 1.6 (1.2–2.0) | 1.0 (1.0–1.3) | 0.008 | 1.1 (1.0–1.4) | 1.0 (0.9–1.2) | 0.020 |
| Lactate (mmol/L) | 4 (3–5) | 2.6 (2–3) | 4 (3–5) | 0.002 | 4.5 (4–5.8) | 4 (3–4.5) | 0.002 |
| Glucose at presentation (mmol/L) | 3.5 (2.5–5.5) | 5.9 (5–7) | 3.1 (2.5–5) | 0.044 | 2.5 (2.0–4.2) | 3.6 (3.0–5.5) | 0.016 |
| AFP (μg/L) | 72.6 (9.7–707) | 56.4 (6.9–7186) | 72.6 (9.7–707) | 0.894 | 10.0 (7.7–704) | 111.5 (46–823) | 0.027 |
| Peak ammonia (μmol/L) | 154 (108–189) | 82 (60–108) | 162 (120–208) | 0.005 | 159 (120–290) | 168.5 (116–184.5) | 0.017 |
| Factor 5 (%) | 23 (12–34) | 125 (8–127) | 22.5 (16–32) | 0.435 | 25 (20–31) | 21 (12–34) | 0.734 |
| Albumin (g/L) | 26 (22–31) | 29 (28–35) | 25 (22–31) | 0.136 | 24 (22–31) | 26 (23.5–29.5) | 0.286 |
| Bilirubin Peak (IU/ml) | 307 (82–398) | 68.5 (30–322) | 320 (211–425) | 0.037 | 218 (76–365) | 353.5 (313.5–522) | 0.002 |
| Phosphate (mmol/L) | 1.1 (0.9–1.4) | 0.9 (0.8–1.3) | 1.2 (0.9–1.6) | 0.236 | 1.4 (1.1–2.3) | 0.9 (0.9–1.2) | 0.033 |
Abbreviations: INR International normalized ratio, AFP Alpha-fetoprotein, Factor V Factor five
p valuea compare recovered versus demised or transplanted patients, p valuesb compare laboratory parameters between three groups i.e., recovered, transplanted and died before transplant