Table 3.

Meta-analyzed adjusted risk of incident cardiovascular disease in SHFS and SHS

	Model 1			Model 2			Model 3
	RR	95% CI	p-value	RR	95% CI	p-value	RR	95% CI	p-value
Cer-16	1.71	(1.18, 2.48)	0.005	1.54	(1.07, 2.23)	0.021	1.85	(1.05, 3.25)	0.033
Cer-20	1.27	(0.98, 1.65)	0.072	1.30	(1.01, 1.68)	0.044	1.03	(0.69, 1.54)	0.876
Cer-22	1.09	(0.76, 1.57)	0.640	1.06	(0.75, 1.5)	0.741	0.70	(0.42, 1.16)	0.162
Cer-24	1.13	(0.77, 1.64)	0.534	1.06	(0.74, 1.52)	0.738	0.65	(0.38, 1.12)	0.122
SM-16	1.62	(0.84, 3.14)	0.154	1.26	(0.65, 2.46)	0.492	2.04	(0.82, 5.05)	0.125
SM-20	0.80	(0.52, 1.24)	0.328	0.75	(0.48, 1.18)	0.209	0.50	(0.27, 0.93)	0.028
SM-22	0.85	(0.57, 1.27)	0.414	0.75	(0.51, 1.13)	0.169	0.48	(0.26, 0.87)	0.016
SM-24	0.88	(0.61, 1.25)	0.470	0.78	(0.54, 1.14)	0.198	0.52	(0.3, 0.89)	0.018

Model 1 includes terms for age, sex, and study site (SHFS only). Model 2 additionally includes terms for education, smoking, physical activity, BMI, waist circumference, LDL-cholesterol, systolic blood pressure, treated hypertension, duration of diabetes, type of diabetes medication used, and treated hyperlipidemia. Model 3 further adjusts for one of the other species: Cer-16 and SM-16 models include adjustment for Cer-22 and SM-22, respectively; Cer-20, -22, -24, and SM-20, -22, and -24 models include adjustment for Cer-16 and SM-16, respectively