Table 4.
Adjusted risk of incident atherosclerotic cardiovascular disease and heart failure in SHFS
| Atherosclerotic cardiovascular disease | Heart failure | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Multivariable model | Sphingolipid adjusted model | Multivariable model | Sphingolipid adjusted model | |||||||||
| HR | 95% CI | p | HR | 95% CI | p | HR | 95% CI | p | HR | 95% CI | p | |
| Cer-16 | 2.01 | (1.35, 2.99) | 0.0006 | 2.26 | (1.09, 4.66) | 0.0276 | 1.77 | (0.73, 4.28) | 0.21 | 2.57 | (0.76, 8.66) | 0.13 |
| Cer-20 | 1.7 | (1.32, 2.19) | 0.00004 | 1.42 | (0.81, 2.47) | 0.2180 | 1.24 | (0.64, 2.39) | 0.52 | 0.83 | (0.32, 2.18) | 0.71 |
| Cer-22 | 1.44 | (0.96, 2.17) | 0.08 | 0.88 | (0.44, 1.75) | 0.7133 | 1.22 | (0.59, 2.52) | 0.59 | 0.67 | (0.26, 1.72) | 0.41 |
| Cer-24 | 1.36 | (0.86, 2.14) | 0.19 | 0.72 | (0.35, 1.48) | 0.3705 | 1.07 | (0.45, 2.58) | 0.87 | 0.45 | (0.14, 1.44) | 0.18 |
| SM-16 | 2.07 | (0.92, 4.67) | 0.08 | 2.97 | (0.96, 9.18) | 0.0588 | 0.98 | (0.28, 3.50) | 0.98 | 0.69 | (0.13, 3.74) | 0.67 |
| SM-20 | 1.09 | (0.62, 1.91) | 0.76 | 0.61 | (0.27, 1.37) | 0.2343 | 1.14 | (0.46, 2.83) | 0.78 | 1.27 | (0.38, 4.22) | 0.69 |
| SM-22 | 1.08 | (0.64, 1.82) | 0.78 | 0.6 | (0.28, 1.31) | 0.2031 | 1.28 | (0.46, 3.57) | 0.63 | 1.59 | (0.41, 6.10) | 0.50 |
| SM-24 | 1.03 | (0.63, 1.70) | 0.91 | 0.61 | (0.30, 1.24) | 0.1709 | 1.28 | (0.49, 3.34) | 0.62 | 1.52 | (0.49, 4.77) | 0.47 |
Number of incident events: Atherosclerotic Heart Disease (n = 99); HF (n = 33). Models are adjusted for age, sex, study site, education, smoking, physical activity, BMI, waist circumference, LDL-cholesterol, systolic blood pressure, treated hypertension, duration of diabetes, type of diabetes medication used, and treated hyperlipidemia; for the sphingolipid adjusted models, Cer-16 and SM-16 models include additional adjustment for Cer-22 and SM-22, respectively; Cer-20, -22, -24, and SM-20, -22, and -24 models include additional adjustment for Cer-16 and SM-16, respectively