Table 1.

Similarities and differences between cancer stem cell and normal stem cell

	Cancer stem cell	Normal stem cell	Reference
Similarities	Markers: CD133, SSEA3, SSEA4, TRA-1–60, etc.		[51]
	Biochemical profile: a higher telomerase activity		[38, 40]
	Proliferation: self-renewal (symmetrically and asymmetrically dividing)		[41, 42]
	Differentiation: differentiate into distinct types of cells		[45]
Differences	Markers: CD20, CD96, CD55, and TIM-3 are not markers for normal stem cells but for CSCs		[51]
	Proliferation: CSCs divide more rapidly than normal stem cells (the cell division rate is an order of magnitude larger)		[40]
	Differentiation: CSCs very few undergo terminal differentiation compared to normal stem cells		[52]