Table 4.
Relationship between dynamic NLR and mortality in 237 patients at 1 month using a generalized additive mixed model
| Outcome | Model Ia | Model IIb | ||
|---|---|---|---|---|
| β (95% CI) | P value | β (95% CI) | P value | |
| Interceptc | 9.086 (8.499, 9.673) | < 0.001 | 4.381 (1.230, 7.559) | 0.007 |
| Dayd | −0.237 (−0.272, − 0.202) | < 0.001 | −0.244 (− 0.279, − 0.208) | < 0.001 |
| Deathe | 2.850 (1.391, 4.301) | < 0.001 | 1.243 (− 0.708, 3.1940) | 0.213 |
| Day × deathf | 0.288 (0.182, 0.394) | < 0.001 | 0.293 (0.186, 0.400) | < 0.001 |
CI Confidence interval, NLR Neutrophil-to-lymphocyte ratio
aModel I: not adjusted for other covariates
bModel II: adjusted for sex; age; history of diabetes; history of chronic kidney disease; baseline NIHSS score; bridging intravenous thrombolysis; cardioembolic stroke; internal carotid artery occlusion; favorable collateral circulation; pneumonia during hospitalization; symptomatic intracerebral hemorrhage during hospitalization; sepsis during hospitalization; anticoagulation during hospitalization; use of invasive mechanical ventilation during hospitalization; use of vasopressors during hospitalization
cIntercept: the mean NLR at day = 0 and death = 0
dDay: the mean decrease in NLR at death = 0 over time (daily)
eDeath: the difference in NLR at day = 0 between nonsurvivors = 1 and survivors = 0
fDay × death: the mean decrease in NLR daily under the condition of nonsurvivors = 1 and survivors = 0