Fig. 1.

SPOP is upregulated in CC patients with pLN metastasis and negatively associated with patient outcome. A The expression of 33 key proteins in our proteomic sequencing data from 5 pLN-positive CC tissues and 5 pLN-negative CC tissues are presented in the heatmap. B The IHC scores of SPOP in the pLN-positive CC group were significantly higher than those in the pLN-negative CC group (P < 0.01). C, D Kaplan–Meier analysis was performed to assess the associations between SPOP expression and the OS (P = 0.042) and RFS (P = 0.022) of patients with CC. Data are presented as the mean ± SEM