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. 2022 Aug 30;20:384. doi: 10.1186/s12967-022-03574-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — In vitro cell cycle assay. A The diagram of cell cycle. B In HeLa cells, cell cycle experiments showed that SPOP knockdown could significantly promote the proportion of G1 phase cells and reduce the proportion of S and G2 phase cells. In SiHa cells, cell cycle experiments showed that SPOP knockdown could significantly promote the percentage of G1 phase cells and reduce the percentage of S phase cells. In ME-180 cells, cell cycle experiments showed that overexpression of SPOP could significantly reduce the proportion of G1 phase cells and increase the proportion of G2 phase cells. In MS751 cells, cell cycle experiments showed that overexpression of SPOP could significantly reduce the proportion of G1 phase cells and increase the proportion of S phase cells