Table 3.
Changes in FEV1/FVC and patterns of ventilatory defect from baseline to 2 weeks, 6 months, and 1 year after surgery
| Before surgery | 2 weeks after surgery | 6 months after surgery | 1 year after surgery | |||
|---|---|---|---|---|---|---|
| Overall | ||||||
| FEV1/FVC (%) | ||||||
| Adjusted mean (SE) | 73.9 (0.3) | 75.1 (0.3) | 74.2 (0.3) | 73.6 (0.4) | ||
| Change from baseline (95% CI)a | Reference | 1.3 (0.8, 1.7) | 0.4 (− 0.1, 0.9) | − 0.3 (− 0.8, 0.3) | ||
| Obstructive pattern | ||||||
| Adjusted proportion (SE) | 20.2 (1.5) | 20.4 (1.6) | 22.1 (1.6) | 25.8 (1.8) | ||
| Odds ratio (95% CI)a | Reference | 1.0 (0.8, 1.1) | 1.0 (0.8, 1.2) | 1.2 (1.0, 1.3) | ||
| Restrictive pattern | ||||||
| Adjusted proportion (SE) | 7.4 (1.0) | 57.8 (1.9) | 33.1 (1.9) | 23.5 (1.8) | ||
| Odds ratio (95% CI)a | Reference | 7.8 (6.0, 10.3) | 4.5 (3.4, 5.8) | 3.2 (2.4, 4.1) | ||
| Type of surgery | ||||||
| FEV1/FVC (%) | ||||||
| Adjusted mean (SE) | ||||||
| Wedge resection/segmentectomy | 73.6 (0.7) | 74.7 (0.7) | 73.4 (0.8) | 73.1 (0.8) | ||
| Lobectomy | 74.0 (0.3) | 75.3 (0.4) | 74.3 (0.4) | 73.6 (0.4) | ||
| Pneumonectomy/bilobectomy | 73.0 (1.7) | 74.6 (1.7) | 77.4 (1.8) | 75.5 (2.0) | ||
| P-values | 0.79 | 0.73 | 0.12 | 0.55 | ||
| Obstructive pattern | ||||||
| Adjusted proportion (SE) | ||||||
| Wedge resection/segmentectomy | 25.1 (3.8) | 22.4 (3.7) | 24.4 (3.9) | 27.2 (4) | ||
| Lobectomy | 21.7 (1.7) | 21.7 (1.7) | 22.3 (1.8) | 25.8 (1.9) | ||
| Bilobectomy/pneumonectomy | 23.0 (7.3) | 17.3 (6.7) | 13.5 (6.1) | 22.0 (7.7) | ||
| P-values | 0.69 | 0.83 | 0.44 | 0.85 | ||
| Restrictive pattern | ||||||
| Adjusted proportion (SE) | ||||||
| Wedge resection/segmentectomy | 4.9 (2) | 44.6 (4.5) | 15.5 (3.4) | 9.1 (2.8) | ||
| Lobectomy | 6.8 (1.1) | 60.0 (2.2) | 35.8 (2.3) | 25.7 (2.1) | ||
| Bilobectomy/pneumonectomy | 26.7 (9) | 72.3 (10.4) | 67.0 (10.9) | 48.2 (11.7) | ||
| P-values | < 0.01 | < 0.01 | < 0.01 | < 0.01 | ||
An obstructive pattern was defined as FEV1/FVC < 70%; a restrictive pattern was defined as both FEV1/FVC ≥ 70% and FVC < 80% predicted
CI confidence interval, FEV1 forced expiratory volume in 1 s; FVC forced expiratory vital capacity, SE standard error
aAdjusted for age, sex, stage, obesity, smoking status, cell type, type of surgery, video-assisted thoracic surgery, postoperative pulmonary complications, and adjuvant treatment