FIG 7.

Phage-resistant UPEC strains display decreased bladder colonization in a murine model of UTI. Female C57BL/6J mice were infected transurethrally with 10⁸ CFU of UTI89 or UTI89-2 (A) or DS566 or DS566-2 (B). After 24 h, bladders were removed, and bladder bacterial burdens were assessed. Points represent individual mice (biological replicates) assayed over two separate experiments. (A) UTI89, n = 11; UTI89-2, n = 12. (B) DS566, n = 12; DS566-2, n = 12. Lines represent median and 95% confidence intervals. Data were analyzed by Mann-Whitney test. ***, P < 0.001; ****, P < 0.0001.