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. 2022 Jul 5;7(4):e00169-22. doi: 10.1128/msphere.00169-22

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Copyright © 2022 Gallichotte et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 3 — Prevaccination immune status impacts postvaccination antibody levels. (A to C) All postvaccination neutralization titers (A) and RBD-binding (B) and NP-binding (C) values were aggregated and stratified based on prevaccination immune status. Pink, seropositive, n = 90; orange, seronegative, n = 63; purple, unknown immune status, n = 25. (A) Dashed line represents the limit of detection. Samples without neutralization detected are plotted at half the limit of detection (PRNT₅₀ = 10). (B, C) Dashed line represents the background level for each assay. Tukey’s multiple-comparison one-way analysis of variance (ANOVA) was used to determine statistical significance. **, P < 0.01; ****, P < 0.0001; ns, not significant.