TABLE 3.
Proteins containing Domains I and II within the same protein or in separate proteinsa
| Protein type | Description | Organism | No. of residuesb | GenBank accession no. |
|---|---|---|---|---|
| Domain I + II | Aut, autotrophic growth | Haemophilus influenzae | 476 | C64127 |
| WaaE, ADP-d-glycero-d-manno-heptose synthase | Helicobacter pylori J99 | 463 | AAD06368 | |
| RfaE, ADP-heptose synthase | Helicobacter pylori 29695 | 461 | AAD07904 | |
| SC2G5.08, bifunctional synthase/transferase | Streptomyces coelicolor | 463 | CAB36595 | |
| Domain I only | RfaE, ADP-heptose synthase | Neisseria meningitidis | 313 | AAD32179 |
| WaaE, ADP-heptose synthase | Burkholderia pseudomallei | 307 | AAD43345 | |
| RfaE, ADP-heptose synthase | Aquifex aeolicus | 315 | AC06797 | |
| TM0960, ribokinase | Thermotoga maritima | 299 | AAD36039 | |
| RbsK, ribokinase | Bacillus subtilis | 293 | P36945 | |
| F20D23.14, ribokinase | Arabidopsis thaliana | 378 | AAD50017 | |
| RbsK, ribokinase | Haemophilus influenzae | 306 | P44331 | |
| RbsK, ribokinase | Escherichia coli | 309 | P05054 | |
| YihV, sugar kinase | Escherichia coli | 298 | P32143 | |
| CscK, fructokinase | Synechocystis sp. | 307 | BAA17561 | |
| RbsK, ribokinase | Schizosaccharomyces pombe | 318 | O60116 | |
| RbsK, ribokinase | Pyrobaculum aerophilum | 305 | AAD00536 | |
| YdjE, sugar kinase | Bacillus subtilis | 320 | O34768 | |
| ScrK, fructokinase | Clostridium beijerinckii | 312 | AAC99323 | |
| RbsK, ribokinase | Lactobacillus sakei | 302 | AAD34338 | |
| K6P2, 6-phosphofructokinase isozyme 2 | Escherichia coli | 309 | P06999 | |
| Domain II only | TagD1, glycerol-3-phosphate cytidylyltransferase | Aquifex aeolicus | 157 | AAC06521 |
| Aut, autotrophic growth | Ralstonia eutropha | 164 | I39548 | |
| TagD, glycerol-3-phosphate cytidylyltransferase | Pyrococcus abyssi | 148 | CAB50222 | |
| PH0735, hypothetical protein | Pyrococcus horikoshii | 148 | BAA29826 | |
| TagD, glycerol-3-phosphate cytidylyltransferase | Archaeoglobus fulgidus | 137 | AAB89835 | |
| MJ1179, hypothetical protein | Methanococcus jannaschii | 149 | B64447 | |
| T6A23.13, phosphoethanolamine cytidylyltransferase | Arabidopsis thaliana | 139 (421) | AAC67351 | |
| TagD2, glycerol-3-phosphate cytidylyltransferase | Aquifex aeolicus | 168 | AAC07343 | |
| TagD, glycerol-3-phosphate cytidylyltransferase | Bacillus subtilis | 129 | P27623 | |
| C39D10.3, glycerol-3-phosphate cytidylyltransferase | Caenorhabditis elegans | 221 | AAA80419 | |
| TagD, glycerol-3-phosphate cytidylyltransferase | Staphylococcus aureus | 132 | AAB51063 | |
| MTH844, autotrophic growth | Methanobacterium thermoautotrophicum | 151 | AAB85342 | |
| CTPT, cholinephosphate cytidylyltransferase | Plasmodium falciparum | 179 (370) | P49587 |
a
Results from a BLAST search with the E. coli RfaE protein as a query. All listed proteins show strong identity with RfaE. Domain I corresponds to the ribokinase family. Domain II corresponds to the cytidylyltransferase superfamily.
b
The number indicates the length of the homologous region that coincides with the length of the protein(s) except for the eukaryotic homologues, for which the total length of the protein is indicated in parentheses.