FIG 1.
Deletion of ccpA results in severely attenuated infections in both normal and diabetic animals. Untreated and STZ treated mice were subcutaneously infected with 1 × 107 CFU WT S. aureus LAC and the isogenic ΔccpA mutant (n = 8 for each category). STZ treated mice infected with WT LAC showed larger lesion area (A) and higher bacterial burdens in the abscess and in the kidney (B, C). Mice infected with the ΔccpA mutant exhibited attenuated infection and lowered metrics in all categories (A–C) in both untreated and STZ treated animals. Statistics: unpaired t tests between groups *, P < 0.05; ****, P < .0001.