TABLE 2.
Drug resistance of AB43-derived strainsa
| Antimicrobial | Drug | AB43 | AB43Δcrispr-cas | AB43ΔabaI | AB43Δcrispr-cas-abaI |
|---|---|---|---|---|---|
| Penicillin | Piperacillin | R | R | I | I |
| β-lactam/β-lactamase inhibitor combinations | Ampicillin-sulbactam | S | R | S | S |
| Piperacillin-tazobactam | S | R | S | S | |
| Ticarcillin-clavulanate | S | R | S | S | |
| Cephems | Cefotaxime | I | R | S | S |
| Ceftazidime | S | R | S | S | |
| Ceftriaxone | I | R | S | S | |
| Cefepime | S | R | S | S | |
| Carbapenems | Imipenem | S | R | S | S |
| Meropenem | S | R | S | S | |
| Aminoglycosides | Amikacin | S | R | S | S |
| Gentamicin | S | R | S | S | |
| Tobramycin | S | R | S | S | |
| Fluoroquinolones | Ciprofloxacin | S | R | S | S |
| Levofloxacin | S | R | S | S | |
| Gatifloxacin | S | I | S | S | |
| Lipopeptides | Polymyxin B | S | S | S | S |
| Tetracyclines | Tetracycline | S | R | S | S |
| Doxycycline | S | R | S | S | |
| Minocycline | S | S | S | S | |
| Folate pathway inhibitors | Sulfisoxazole | S | R | S | S |
| Roxithromycin | S | R | S | S | |
| Rifampicin | S | R | S | S | |
| Chloramphenicol | S | R | S | S |
a
R, resistance; I, intermediate; S, sensitivity. Boldface indicates antimicrobial susceptibility results change.