TABLE 2.
Baseline biochemical and hematologic markers in chronic Chagas disease subjects with or without benznidazole-induced dermatitis
| Variable (unit) | Benznidazole-induced adverse effectsa |
Reference values | ||
|---|---|---|---|---|
| Yes (n = 22) | No (n = 37) | P valueb | ||
| Age (yr, range) | 36 (25–50) | 38 (23–52) | 0.93 | NA |
| Sex (no. female/no. male) | 11/11 | 27/10 | 0.27 | NA |
| Arterial hypertension (no. subjects/total evaluated, %) | 32 | 11 | 0.29 | 120–80 mm Hg |
| IgE (UI/mL) | 76 (1–764) | 86 (4–664) | 0.58 | 0.1–100 |
| Leukocytes (total/mL) | 7,550 (5,400–9,900) | 6,900 (4,500–9,900) | 0.24 | 4,500–10,000 |
| Hemoglobin (g/dL) | 14 (12–16) | 13 (11–16) | 0.08 | 13.3–16 |
| Platelets (no. ×103/mL) | 179 (246–338) | 239 (159–311) | 0.40 | 150–450 |
| Neutrophils (no./μL) | 3,95 (2.6–7.2) | 4 (2.3–7.1) | 0.88 | 2,100–6,200 |
| Eosinophils (no./μL) | 0.26 (0–1.02) | 0.16 (0–0.74) | 0.08 | 0–500 |
| Basophils (no./μL) | 0.05 (0–0.13) | 0.05 (0–0.13) | 0.69 | 0–200 |
| Lymphocytes (no./μL) | 2.35 (1.3–4.5) | 2 (1.2–3.5) | 0.27 | 1,300–3,500 |
| Monocytes (no./μL) | 0.46 (0.17–1.03) | 0.45 (0–0.95) | 0.39 | 30–1,000 |
| Creatinine (mg/dL) | 0.76 (0.60–1.20) | 0.7 (0.4–1.18) | 0.24 | 0.7–1.3 |
| Uremia (g/L) | 0.32 (0.20–0.47) | 0.27 (0.14–0.41) | 0.04 | 0.1–0.5 |
| Cholesterol (mg/dL) | 208 (135–264) | 179 (112–261) | 0.15 | 100–200 |
| Triglycerides levels (mg/dL) | 148 (56–448) | 120 (33–529) | 0.36 | 50–150 |
| HDL (mg/dL) | 49 (33–79) | 43 (27–67) | 0.05 | 30–70 |
| LDL (mg/dL) | 126 (75–170) | 104 (0.84–187) | 0.03 | 0–130 |
| TSH levels (U/mL) | 2.16 (1.10–23) | 2.68 (0.014–5.91) | 0.65 | 0.27–4.2 |
| FT4 levels (ng/dL) | 1.14 (0.91–1.81 | 1.23 (0.95–2.05) | 0.14 | 0.93–1.7 |
| Uric acid (mg/dL) | 4.55 (2.5–7.2) | 3.7 (2.2–8) | 0.27 | 2.5–6 |
| GOT levels (IU/L) | 25 (7–162) | 19 (11–49) | 0.04 | 0–38 |
| GPT levels (IU/L) | 34 (8–115) | 20 (6–80) | 0.12 | 0.41 |
| Alkaline phosphatase (IU/mL) | 189 (0–331) | 186 (72–438) | 0.53 | 65–300 |
| Glucose (g/L) | 0.93 (0.77–119) | 0.91 (0.7–110) | 0.64 | 0.7–1.1 |
a
Data for continuous variables are shown as medians and ranges.
b
For univariate analysis, two-sample t test, Wilcoxon rank sum test and the Fisher exact test were used, as appropriate. Italics indicate P values lower or equal to 0.05. HDL, high-density lipoprotein; LDL, low-density lipoprotein; TSH, thyroid-stimulating hormone; FT4, free thyroxine; GOT, glutamic-oxaloacetic transaminase; GPT, glutamic-pyruvic transaminase.