Treatment effect of B. coagulans, COSs, and synbiotic on DSS-induced colon injury and inflammation. (A) Microscopic images of proximal colonic tissues stained with H&E. Scale bars represent 100 μm. The right images are the enlarged part of the left images. Arrows indicate the damage of colon. (B) Histological score calculated after microscopic analyses of the colons. (C) Myeloperoxidase (MPO) activity in proximal colonic tissues. Data were shown as means ± SEM. Data with different superscript letters (a and b) were significantly different (P < 0.05) according to one-way ANOVA followed by Tukey’s test. Ctrl: healthy control; DSS: DSS-treated group; B. co, COSs, and Synbiotic: supplementation of B. coagulans spores, COSs, or spores + COSs, respectively.