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. 2022 Jul 12;10(4):e00373-22. doi: 10.1128/spectrum.00373-22

TABLE 3.

Identified druggable targets with drug names

Serial no. Accession no. Protein name DrugBank ID Drug namea Bit score Query length (aa)b
1 tr|Q5ZS52 RNA polymerase sigma factor RpoH DB08874 Fidaxomicin 103.605 318
2 tr|Q5ZT04 RNA polymerase sigma factor RpoD DB08226 and DB08266 Myxopyronin B and methyl [(1E,5R)-5-{3-[(2E,4E)-2,5-dimethyl-2,4-octadienoyl]-2,4-dioxo-3,4-dihydro-2H-pyran-6-yl}hexylidene]carbamate 302.368 248
3 tr|Q5ZUP0 UDP-N-acetylmuramate–l-alanyl-gamma-d-glutamyl-meso-2,6-diaminoheptandioate ligase DB01673, DB03909, and DB04395 Uridine-5′-diphosphate-N-acetylmuramoyl-l-alanine,adenosine-5′-[β, γ-methylene]triphosphate, and phosphoaminophosphonic acid-adenylate ester 145.591 398
4 tr|Q5ZXL1 Multidrug resistance protein DB03825, DB04209, and DB03619 Rhodamine 6G, dequalinium, and deoxycholic acid 427.557 1,020
5 tr|Q5ZX17 Peptidoglycan d,d-transpeptidase FtsI DB00303 and DB00671 Ertapenem and cefixime 122.094 632
6 tr|Q5ZVR5 Peptidoglycan d,d-transpeptidase MrdA DB01598, DB01329, DB01327, DB01163, DB01328, DB01413, DB01415, DB00948, DB00438, DB00303, and DB06211 Imipenem, cefoperazone, cefazolin, amdinocillin, cefonicid, cefepime, ceftibuten, mezlocillin, ceftazidime, ertapenem, and doripenem 486.493 612
7 tr|Q5ZZI4 Amino acid permease DB00123, DB00125, and DB00129 l-Lysine, l-arginine, and ornithine 155.606 424
a

Drug names correspond respectively to the DrugBank ID numbers listed in Table 3, column 4.

b

aa, amino acids.