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Model of MLV integration in vivo. The MLV preintegration complex (PIC) is targeted to enhancers and promoters by the BET proteins, while the lack of an interaction between MLV PIC and BET proteins retargets integration toward promoters and gene bodies by the implication of an unknown host factor or chromatin feature or a direct implication of the MLV integrase. The strong MLV LTR enhancer/promoter can drive oncogenesis, even after retargeting.
