FIG 2.

Schematic of the HIV-1 genome and p6 mutants. (A) The HIV-1 genome is shown with an expanded view of p6 mutations including PTAPPE insertion and PIDKELY deletion in p6^Gag, as well as NSPTRG insertion and DRQGTVS deletions in p6*. (B) HIV-1 wild-type(WT) and p6^Gag mutants. ΔPTAP, a mutant bearing the deletion of the original ₇PTAP₁₀ motif was constructed and used as a control for deficiency of virus release; insPTAP, PTAPPE insertion; Δ7, ₃₀PIDKELY₃₆ deletion in p6^Gag; PΔ7, the double mutation bearing insPTAP and Δ7; ΔY, deletion of the 36th residue in p6^Gag; and Δ6, ₃₀PIDKEL₃₅ deletion in p6^Gag. Sequences of mutations are highlighted and compared with HIV-1 WT. To help distinguish the mutants, we included the first and last amino acid numbers for some mutants in this figure, but not shown in other figures.