TABLE 1.
Summarized NTM data from the German CF registry 2015–2020
| Patient characteristics | 2015 | 2016 | 2017 | 2018 | 2019 | 2020 |
|---|---|---|---|---|---|---|
| Patients in registrya | 5,462 | 5,512 | 5,869 | 6,031 | 6,108 | 6,295 |
| Patients tested for NTM | 1,989 (36.4e) | 1,775 (32.2b) | 2,026 (34.5b) | 2,178 (36.1b) | 2,316 (37.9b) | 2,112 (33.6b) |
| Patients with positive culturee | 106 (1.9b;5.3c) | 133 (2.4b;7.5c) | 177 (3.0b;8.7c) | 176 (2.9b; 8.1c) | 174 (2.9b;7.5c) | 179 (2.8b;8.5b) |
| M. abscessus | 66 (62.3d) | 79 (59.4d) | 91 (51.4d) | 82 (46.6d) | 84 (47.5d) | 94 (52.5d) |
| mabs | 2 | 6 | 19 | 17 | 24 | 26 |
| mmas | 0 | 3 | 12 | 8 | 6 | 10 |
| mbol | 3 | 3 | 7 | 3 | 3 | 1 |
| Subspecies not known | 61 | 67 | 53 | 54 | 51 | 57 |
| MAC | 16 (15.1d) | 38 (28.6d) | 48 (27.1d) | 55 (31.3d) | 51 (28.8d) | 65 (36.3d) |
| Others | 22 (20.8d) | 14 (10.5d) | 37 (20.9d) | 39 (22.2d) | 42 (23.7d) | 35 (19.6d) |
| M. kansasii | 2 | 1 | 2 | 4 | 2 | 0 |
| M. fortuitum | 2 | 0 | 3 | 0 | 6 | 3 |
| M. gordonae | 1 | 4 | 15 | 15 | 17 | 13 |
| M. chelonae | 2 | 3 | 4 | 4 | 7 | 9 |
| Miscellaneous | 15 | 6 | 13 | 16 | 10 | 10 |
| Unknown | 2 (1.9d) | 4 (3.0d) | 4 (2.3d) | 5 (2.8d) | 1 (0.6d) | 1 (0.6d) |
a
In each year, patients who had a prior transplant were excluded.
b
Percentage of all patients in registry.
c
Percentage of tested patients.
d
Percentage of patients with positive NTM culture. NTM, nontuberculous mycobacteria; mabs, M. abscessus subsp. abscessus; mmas, M. abscessus subsp. massiliense; mbol, M. abscessus subsp. bolletii; MAC, Mycobacterium avium complex.
e
Negative patients included those who do not produce sputum or were not investigated for NTM.