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Evolution of P. aeruginosa toward tobramycin, ceftazidime, or ceftazidime-avibactam resistance in rich laboratory medium, urine, or SCFM. MICs for the antibiotic used as selective agent were determined every 5 days in populations that evolved 30 days in the presence of tobramycin, ceftazidime, or ceftazidime-avibactam in rich laboratory medium (RM), urine, or SCFM. Raw data for each evolved replicate are included in Tables S1 and S2.
