TABLE 1.
Genomic variations identified in representative clones of tobramycin and ceftazidime ALEs in urine, SCFM and rich medium
| Clone | Gene | Genetic event | Amino acid changea |
|---|---|---|---|
| TobU | fusA | 2011A→G | Thr671Ala |
| orfK | 355G→A | Glu119Lys | |
| nuoD | 183_184insC | Lys63fs | |
| TobS | ptsP | 1135dupG | Ala379fs |
| fusA | 2038C→T | Arg680Cys | |
| orfH | 286C→T | Arg96* | |
| TobRM | ptsP | 2156delG | Glu677fs |
| fusA | 1634G→A | Gly545Asp | |
| orfN | 148delG | Val50fs | |
| pmrB | 853G→C | Val285Leu | |
| CazU | mpl | 353C→G | Thr118Ser |
| ftsL | 176G→A | Gly59Asp | |
| CazS | mpl | 706A→C | Thr236Pro |
| dacB | 326G→A | Gly109Asp | |
| clpS | 248A→C | Gln83Pro | |
| ftsI | 1510C→T | Arg504Cys | |
| CazRM | mpl | 416T→G | Val139Gly |
| dacB | 343C→T | Gly115Ser | |
| nalD | 32G→T | Thr11Asn | |
| pitA | 367A→C | Thr123Pro | |
| del299,648 bp | del3200274–3499932 | ||
| Caz-AviU | mpl | 742C→T | Gln248* |
| ftsL | 176G→A | Gly59Asp | |
| Caz-AviS | anmK | 197G→A | Trp66* |
| mpl | 111delC | Met38fs | |
| mpl | 104A→C | Tyr35Ser | |
| Caz-AviRM | PA14_45890 | 1001G→A | Ser334Leu |
| ftsI | 1567C→T | Val523Met | |
| ftsI | 1511C→T | Arg504His | |
| clpA | 1634A→G | Tyr545Cys | |
| del220701 bp | del3288650–3509351 | ||
a
An asterisk indicates the mutation led to a stop codon.