TABLE 2.

Highest-ranking genes for association with mcr-9 presence

Genea	Comment	Odds ratio	Bonferroni-adjusted P value
smc	Chromosome partition protein Smc	∞	1.60E−06
dcm2	DNA-cytosine methyltransferase	∞	1.60E−06
pcoE2	Putative copper-binding protein PcoE	∞	2.88E−05
hns2	DNA-binding protein H-NS, plasmid	∞	3.36E−05
group_10390	Tn3 family transposase ISEc63	∞	3.36E−05
hipA	Serine/threonine-protein kinase toxin HipA	∞	3.36E−05
rcnR2	Transcriptional repressor RcnR	∞	0.00030219
hha2	Hemolysin expression-modulating protein Hha	∞	0.00036934
uvrD2	DNA helicase II	∞	0.00036934
parM	Plasmid segregation protein	∞	0.00036934
higB-1	Toxin HigB-1	∞	0.00036934
group_1846	Tn3 family transposase ISEc63	∞	0.00036934
dam2	DNA adenine methylase	∞	0.00036934
repB	RepFIB replication protein A	∞	0.00036934
traC	Protein TraC	∞	0.00036934
group_7173	Stable plasmid inheritance protein	∞	0.00036934
yjcD	Putative ATP-dependent DNA helicase YjcD	304	0.00054522
umuD2	Protein UmuD	∞	0.00283164
dsbC_2	Thiol:disulfide interchange protein DsbC	∞	0.00283164
virB	Virulence regulon transcriptional activator VirB	∞	0.00283164
umuC_3	Protein UmuC	∞	0.00283164
group_7174	IS110 family transposase ISEsa2	142.5	0.00540586
merA	Mercuric reductase	∞	0.01698985
fieF_2	Ferrous-iron efflux pump FieF	90.7	0.03283809
arsB_2	Arsenical pump membrane protein	67.5	0.04368339
group_7063	ISNCY family transposase ISEsa1	67.5	0.04368339
group_8953	ISNCY family transposase ISBcen27	67.5	0.04368339
arsH	NADPH-dependent FMNb reductase ArsH	67.5	0.04368339
arsC2	Arsenate reductase	67.5	0.04368339

^aHypothetical proteins not included.

^bFMN, flavin mononucleotide.