TABLE 2.
Summary of the characteristics of the 38 carbapenem-resistant K. pneumoniae strains, including MLST types and drug resistance genesa
| MLST type |
No. of isolates |
Hospital(s) | Carbapenemase genes(s) | Extended-spectrum β-lactamase-encoding gene(s) | 16S rRNA methylase gene(s) |
Aminoglycoside acetyltransferase-encoding gene(s) | Mutation(s) in DNA gyrase |
|
|---|---|---|---|---|---|---|---|---|
| GyrA | ParC | |||||||
| ST15 | 1 | A | bla NDM-1 | blaCTX-M-15, blaSHV-106 | armA | aac(6′)-Ib-cr, aac(3)-IId, aadA2, aadA16 | S83F, D87A | S80I |
| ST16 | 2 | B (1/2), F (1/2) | blaNDM-1 (1/2), blaNDM-5 (1/2) | blaCTX-M-15, blaSHV-26, blaSHV-78, blaSHV-98 | armA, rmtB (1/2) | aac(6′)-Ib-cr, aadA2, aac(6′)-Ib3 (1/2), aac(3)-Ild (1/2), aadA16 (1/2) | S83F, D87N | E84K |
| ST17 | 2 | G | bla NDM-1 | bla CTX-M-14 | —b | aac(3)-Iid, aac(6′)-Ib-cr, aac(6′)-Ib3 | — | — |
| ST36 | 1 | J | bla NDM-1 | blaCTX-M-15, blaSHV-11, blaSHV-13, blaSHV-70 | armA | aac(3)-Iid, aadA16 | — | — |
| ST42 | 1 | A | bla NDM-4 | blaCTX-M-15, blaSHV-26, blaSHV-78, blaSHV-98 | — | aac(3)-Iid, aac(6′)-Ib-cr, aadA16 | S83L, D87Y | S80I |
| ST101 | 11 | A (8/11),E (2/11),I(1/11) | blaNDM-1 (3/11), blaNDM-5 (8/11) | bla CTX-M-15 | armA(1/11), rmtB (9/11) | aac(3)-Ild (8/11), aac(6′)-Ib-cr (10/11), aadA1 (1/11), aadA2 (8/11), aadA16 (7/11) | S83Y, D87G (8/11) | S80I (8/11) |
| ST147 | 10 | A (8/10), C (1/10), G (1/10) | blaNDM-1 (9/10), blaNDM-5 (1/10) | blaCTX-M-15, blaSHV-11 | rmtB (1/10) | aac(3)-Ild (5/10), aac(6′)-Ib-cr (9/10), aac(6′)-Ib3, (2/10), aadA1 (9/10), aadA2 (4/10), aadA16 (5/10) | S83I (9/10), S83Y (1/10), D87A (1/10) | S80I |
| ST273 | 1 | H | bla NDM-7 | blaCTX-M-15, blaSHV-11 | — | aac(3)-Ild, aac(6′)-Ib-cr, aadA16, aph(3′)-I, aph(6)-Id | S83I | S80I |
| ST394 | 1 | C | bla NDM-5 | bla CTX-M-15 | rmtB | aadA2, aadA16 | — | — |
| ST401 | 1 | J | bla NDM-1 | bla CTX-M-15 | armA | aac(6′)-Ib-cr, aadA16 | — | — |
| ST420 | 1 | E | bla NDM-1 | blaCTX-M-15, blaSHV-75 | armA | aac(3)-IId, aadA16 | — | — |
| ST534 | 1 | A | bla NDM-7 | blaCTX-M-15, blaSHV-11, blaSHV-13, blaSHV-70, blaSHV-77, blaSHV-80 | — | aac(3)-Iid, aac(6′)-Ib-cr, aadA16 | S83I | S80I |
| ST1655 | 1 | G | bla NDM-1 | blaCTX-M-15, blaSHV-26, blaSHV-78, blaSHV-98 | armA | aac(3)-Iid, aac(6′)-Ib-cr, aadA16 | — | — |
| ST4029 | 2 | G | bla NDM-1 | blaCTX-M-15, blaSHV-40, blaSHV-56, blaSHV-79, blaSHV-85, blaSHV-89 | — | aac(6′)-Ib-cr, aadA1, aac(6′)-Ib | — | — |
| ST4030 | 1 | G | bla NDM-7 | blaCTX-M-15, blaSHV-187 | — | aac(3)-Iid, aac(6′)-Ib-cr, aadA16 | S83I | S80I |
| ST5912 | 1 | D | bla NDM-7 | blaCTX-M-15, blaSHV-26, blaSHV-78, blaSHV-98 | — | aac(6′)-Ib-cr, aadA16 | S83F, D87N | E84K |
a
Numbers in parenthesis indicate that the number of isolates with resistant genes or amino acid mutations per each ST isolate. No parenthesis indicate that all each ST isolate had resistant genes or amino acid mutations.
b
— means that the isolate has no mutation, i.e. S83S.