TABLE 2.
Prevalence of type-specific β-HPV infection in oral rinse samples of HNSCC cases and matched controls
| Controls (N = 241) | HNSCC cases |
|||||
|---|---|---|---|---|---|---|
| Lip and oral cavity (N = 198) | Pharynx (N = 43) | Larynx (N = 215) | Other subsites (N = 37) | Any HNSCC (N = 493) |
||
| β-HPV typea | No. (%) | No. (%) | No. (%) | No. (%) | No. (%) | No. (%) |
| Any β-Positive | 93 (38.6) | 90 (45.5) | 10 (23.3) | 96 (44.7) | 20 (54.1) | 216 (43.8) |
| Single type | 41 (17.0) | 45 (22.7) | 7 (16.3) | 41 (19.1) | 7 (18.9) | 100 (20.3) |
| Multiple type | 52 (21.6) | 45 (22.7) | 3 (7.0) | 55 (25.6) | 13 (35.1) | 116 (23.5) |
| Any β1 | 53 (22.0) | 59 (29.8) | 5 (11.6) | 62 (28.8) | 10 (27.0) | 136 (27.6) |
| HPV5 | 14 (5.8) | 15 (7.6) | 2 (4.7) | 11 (5.1) | 2 (5.4) | 30 (6.1) |
| HPV8 | 4 (1.7) | 6 (3.0) | 0 | 5 (2.3) | 2 (5.4) | 13 (2.6) |
| HPV12 | 8 (3.3) | 14 (7.1) | 0 | 8 (3.7) | 0 | 22 (4.4) |
| HPV14 | 4 (1.7) | 8 (4.0) | 1 (2.3) | 6 (2.8) | 2 (5.4) | 17 (3.5) |
| HPV19 | 8 (3.3) | 10 (5.1) | 0 | 8 (3.7) | 2 (5.4) | 20 (4.1) |
| HPV20 | 5 (2.1) | 2 (1.0) | 0 | 4 (1.9) | 3 (8.1) | 9 (1.8) |
| HPV21 | 11 (4.6) | 8 (4.0) | 1 (2.3) | 16 (7.4) | 3 (8.1) | 28 (5.7) |
| HPV24 | 10 (4.2) | 12 (6.1) | 0 | 14 (6.5) | 4 (10.8) | 30 (6.1) |
| HPV25 | 2 (0.8) | 0 | 0 | 1 (0.5) | 0 | 1 (0.2) |
| HPV36 | 3 (1.2) | 1 (0.5) | 0 | 1 (0.5) | 1 (2.7) | 3 (0.6) |
| HPV47 | 6 (2.5) | 8 (4.0) | 1 (2.3) | 8 (3.7) | 4 (10.8) | 21 (4.3) |
| HPV93 | 3 (1.2) | 3 (1.5) | 0 | 5 (2.3) | 1 (2.7) | 9 (1.8) |
| HPV98 | 6 (2.5) | 4 (2.0) | 0 | 3 (1.4) | 2 (5.4) | 9 (1.8) |
| HPV99 | 9 (3.7) | 4 (2.0) | 0 | 5 (2.3) | 4 (10.8) | 13 (2.6) |
| HPV105 | 9 (3.7) | 12 (6.1) | 2 (4.7) | 4 (1.9) | 1 (2.7) | 19 (3.9) |
| HPV118 | 1 (0.4) | 2 (1.0) | 0 | 1 (0.5) | 1 (2.7) | 4 (0.8) |
| HPV124 | 19 (7.9) | 8 (4.0) | 0 | 13 (6.1) | 2 (5.4) | 23 (4.7) |
| HPV143 | 2 (0.8) | 1 (0.5) | 0 | 1 (0.5) | 0 | 2 (0.4) |
| Any β2 | 73 (30.3) | 57 (28.8) | 6 (12.8) | 73 (34.0) | 17 (46.0) | 153 (31.0) |
| HPV9 | 9 (3.7) | 6 (3.0) | 1 (2.3) | 5 (2.3) | 2 (5.4) | 14 (2.8) |
| HPV15 | 5 (2.1) | 1 (0.5) | 0 | 4 (1.9) | 1 (2.7) | 6 (1.2) |
| HPV17 | 5 (2.1) | 0 | 0 | 0 | 0 | 0 |
| HPV22 | 8 (3.3) | 6 (3.0) | 0 | 4 (1.9) | 0 | 10 (2.0) |
| HPV23 | 20 (8.3) | 16 (8.1) | 2 (4.7) | 21 (9.8) | 5 (13.5) | 44 (8.9) |
| HPV37 | 2 (0.8) | 1 (0.5) | 0 | 0 | 2 (5.4) | 3 (0.6) |
| HPV38 | 22 (9.1) | 19 (9.6) | 1 (2.3) | 16 (7.4) | 3 (8.1) | 39 (7.9) |
| HPV80 | 0 | 0 | 0 | 3 (1.4) | 0 | 3 (0.6) |
| HPV100 | 4 (1.7) | 10 (5.1) | 0 | 10 (4.7) | 1 (2.7) | 21 (4.3) |
| HPV104 | 1 (0.4) | 1 (0.5) | 0 | 6 (2.8) | 1 (2.7) | 8 (1.6) |
| HPV107 | 4 (1.7) | 1 (0.5) | 0 | 6 (2.8) | 1 (2.7) | 8 (1.6) |
| HPV110 | 3 (1.2) | 3 (1.5) | 0 | 7 (3.3) | 0 | 10 (2.0) |
| HPV111 | 13 (5.4) | 3 (1.5) | 2 (4.7) | 5 (2.3) | 4 (10.8) | 14 (2.8) |
| HPV113 | 1 (0.4) | 0 | 0 | 2 (0.9) | 0 | 2 (0.4) |
| HPV120 | 7 (2.9) | 5 (2.5) | 1 (2.3) | 5 (2.3) | 4 (10.8) | 15 (3.0) |
| HPV122 | 8 (3.3) | 2 (1.0) | 1 (2.3) | 10 (4.7) | 2 (5.4) | 15 (3.0) |
| HPV145 | 14 (5.8) | 10 (5.1) | 0 | 13 (6.1) | 5 (13.5) | 28 (5.7) |
| HPV151 | 2 (0.8) | 1 (0.5) | 0 | 4 (1.9) | 3 (8.1) | 8 (1.6) |
| HPV159 | 10 (4.2) | 5 (2.5) | 0 | 15 (7.0) | 2 (5.4) | 22 (4.5) |
| HPV174 | 3 (1.2) | 7 (3.5) | 0 | 10 (4.7) | 3 (8.1) | 20 (4.1) |
| Any β3 | 20 (8.3) | 19 (9.6) | 2 (4.7) | 24 (11.2) | 6 (16.2) | 51 (10.3) |
| HPV49 | 11 (4.6) | 7 (3.5) | 1 (2.3) | 14 (6.5) | 3 (8.1) | 25 (6.0) |
| HPV75 | 3 (1.2) | 3 (1.5) | 0 | 6 (2.8) | 2 (5.4) | 11 (2.2) |
| HPV76 | 9 (3.7) | 11 (5.6) | 0 | 10 (4.7) | 2 (5.4) | 23 (4.7) |
| HPV115 | 2 (0.8) | 3 (1.5) | 1 (2.3) | 1 (0.5) | 0 | 5 (1.0) |
| Any β4 | 3 (1.2) | 2 (1.0) | 0 | 1 (0.5) | 2 (5.4) | 5 (1.0) |
| HPV92 | 3 (1.2) | 2 (1.0) | 0 | 1 (0.5) | 2 (5.4) | 5 (1.0) |
| Any β5 | 5 (2.1) | 2 (1.0) | 0 | 3 (1.4) | 1 (2.7) | 6 (1.2) |
| HPV96 | 4 (1.7) | 1 (0.5) | 0 | 2 (1.0) | 1 (2.7) | 4 (0.8) |
| HPV150 | 1 (0.4) | 1 (0.5) | 0 | 1 (0.5) | 0 | 2 (0.4) |
a
HPV152 was not detected in saliva samples of cases and controls.