TABLE 3.
Prevalence of type-specific γ-HPV infection in oral rinse samples of HNSCC cases and matched controls
| γ-HPV typea | Controls (N = 239) | HNSCC cases |
||||
|---|---|---|---|---|---|---|
| Lip and oral cavity (N = 197) | Pharynx (N = 43) | Larynx (N = 214) | Other subsites (N = 37) | Any HNSCC (N = 491) | ||
| Any γ-positive | 59 (24.7) | 49 (24.9) | 7 (16.3) | 65 (30.4) | 7 (18.92) | 128 (26.1) |
| Single type | 37 (15.5) | 31 (15.7) | 4 (9.3) | 37 (17.3) | 6 (16.22) | 78 (15.9) |
| Multiple type γ | 22 (9.2) | 18 (9.1) | 3 (7.0) | 28 (13.1) | 1 (2.70) | 50 (10.2) |
| γ-species1 | 3 (1.3) | 10 (5.1) | 1 (2.3) | 10 (4.7) | 0 | 21 (4.3) |
| HPV4 | 2 (0.8) | 6 (3.1) | 0 | 5 (2.3) | 0 | 11 (2.2) |
| HPV65 | 1 (0.4) | 2 (1.0) | 1 (2.3) | 2 (0.9) | 0 | 5 (1.0) |
| HPV95 | 0 | 3 (1.5) | 0 | 3 (1.4) | 0 | 6 (1.2) |
| γ-species 4 | ||||||
| HPV156 | 10 (4.2) | 5 (2.5) | 0 | 11 (5.1) | 0 | 16 (3.3) |
| γ-species 5 | ||||||
| HPV60 | 0 | 2 (1.0) | 0 | 1 (0.5) | 0 | 3 (0.6) |
| γ-species 6 | ||||||
| HPV108 | 2 (0.8) | 0 | 0 | 1 (0.5) | 0 | 1 (0.2) |
| γ-species 7 | 17 (7.1) | 13 (6.6) | 2 (4.7) | 12 (5.6) | 1 (2.7) | 28 (5.7) |
| HPV123 | 0 | 3 (1.5) | 0 | 4 (1.9) | 0 | 7 (1.4) |
| HPV134 | 13 (5.4 | 8 (4.1) | 1 (2.3) | 3 (1.4) | 0 | 12 (2.4) |
| HPV149 | 4 (1.9) | 1 (0.5) | 0 | 4 (1.9) | 1 (2.7) | 6 (1.2) |
| HPV170 | 0 | 1 (0.5) | 1 (2.3) | 1 (0.5) | 0 | 3 (0.6) |
| γ-species 8 | 5 (2.1) | 2 (1.0) | 0 | 5 (2.3) | 0 | 7 (1.4) |
| HPV112 | 0 | 1 (0.5) | 0 | 0 | 0 | 1 (0.2) |
| HPV164 | 0 | 1 (0.5) | 0 | 3 (1.4) | 0 | 4 (0.8) |
| HPV168 | 5 (2.1) | 0 | 0 | 2 (0.9) | 0 | 2 (0.4) |
| γ-species 9 | ||||||
| HPV129 | 0 | 1 (0.5) | 0 | 1 (0.5) | 0 | 2 (0.4) |
| γ-species10 | 17 (7.1) | 10 (5.1) | 4 (9.3) | 16 (7.5) | 1 (2.7) | 31 (6.3) |
| HPV121 | 3 (1.3) | 4 (2.0) | 2 (4.7) | 7 (3.3) | 1 (2.7) | 14 (2.9) |
| HPV130 | 8 (3.4) | 5 (2.5) | 0 | 7 (3.3) | 0 | 12 (2.4) |
| HPV133 | 7 (2.9) | 1 (0.5) | 2 (4.7) | 7 (3.3) | 1 (2.7) | 11 (2.2) |
| HPV180 | 3 (1.3) | 2 (1.0) | 2 (4.7) | 4 (1.9) | 1 (2.7) | 9 (1.8) |
| γ-species 11 | 2 (0.9) | 2 (1.0) | 0 | 2 (0.9) | 1 (2.7) | 5 (1.0) |
| HPV126 | 1 (0.4) | 0 | 0 | 0 | 1 (2.7) | 1 (0.2) |
| HPV169 | 1 (0.4) | 2 (1.0) | 0 | 2 (0.9) | 0 | 4 (0.8) |
| HPV202 | 1 (0.4) | 0 | 0 | 0 | 0 | 0 |
| γ-species 12 | 7 (2.9) | 3 (1.5) | 0 | 4 (1.9) | 1 (2.7) | 8 (1.6) |
| HPV127 | 1 (0.4) | 2 (1.0) | 0 | 1 (0.5) | 0 | 3 (0.6) |
| HPV132 | 4 (1.7) | 1 (0.5) | 0 | 4 (1.9) | 1 (2.7) | 6 (1.2) |
| HPV148 | 1 (0.4) | 0 | 0 | 0 | 0 | 0 |
| HPV199 | 1 (0.4) | 0 | 0 | 0 | 0 | 0 |
| γ-species 13 | ||||||
| HPV128 | 4 (1.7) | 3 (1.5) | 0 | 6 (2.8) | 0 | 9 (1.8) |
| γ-species 15 | ||||||
| HPV179 | 1 (0.4) | 1 (0.5) | 0 | 7 (3.3) | 1 (2.7) | 9 (1.8) |
| γ-species 19 | 3 (1.3) | 1 (0.5) | 0 | 12 (5.6) | 1 (2.7) | 14 (2.9) |
| HPV161 | 2 (0.84) | 0 | 0 | 12 (5.61) | 1 (2.70) | 13 (2.7) |
| HPV162 | 1 (0.42) | 1 (0.51) | 0 | 0 | 0 | 1 (0.2) |
| HPV166 | 0 | 1 (0.51) | 0 | 0 | 0 | 1 (0.2) |
| γ-species 20 | ||||||
| HPV163 | 0 | 0 | 0 | 1 (0.5) | 0 | 1 (0.2) |
| γ-species 21 | ||||||
| HPV167 | 2 (0.8) | 3 (1.5) | 1 (2.3) | 1 (0.5) | 0 | 5 (1.0) |
| γ-species 22 | ||||||
| HPV172 | 2 (0.8) | 1 (0.5) | 0 | 4 (1.9) | 0 | 5 (1.02) |
| γ-species 23 | ||||||
| HPV175 | 4 (1.7) | 2 (1.0) | 0 | 7 (3.3) | 1 (2.7) | 10 (2.0) |
| γ-species 24 | 8 (3.4) | 6 (3.1) | 0 | 4 (1.9) | 0 | 10 (2.0) |
| HPV178 | 3 (1.3) | 3 (1.5) | 0 | 2 (0.9) | 0 | 5 (1.0) |
| HPV197 | 5 (2.1) | 3 (1.5) | 0 | 2 (0.9) | 0 | 5 (1.0) |
| γ-species 27 | 0 | 2 (0.4) | ||||
| HPV201 | 0 | 1 (0.5) | 0 | 1 (0.5) | 0 | 2 (0.4) |
| SD2 | 7 (2.9) | 6 (3.1) | 1 (2.33) | 9 (4.2) | 2 (5.4) | 18 (3.7) |
a
The following γ-HPV types were not detected in the oral rinse samples of subjects: HPV48, HPV119, HPV50, HPV131, HPV88, HPV165, HPV101, HPV171, HPV103, HPV173, HPV109, HPV184, HPV116, and HPV200.