TABLE 1.
Properties of plasmid-encoded TA loci
| Locusa | Organism | Toxin (no. of aa) | Target | Antitoxin (no. of aa) | Protease | PSK | Reference(s) |
|---|---|---|---|---|---|---|---|
| ccd of F | E. coli | CcdB (101) | DNA gyrase | CcdA (72) | Lon | Yes | 57, 58, 67, 95, 96 |
| pem/parD of R100/R1 | E. coli | PemK/Kid (110) | DnaB? | PemI/Kis (84) | Lon | Yes | 10, 77, 91, 92 |
| phd-doc of P1 | E. coli | Doc (126) | Unknown | Phd (73) | ClpXP | Yes | 46, 47 |
| parDE of RK2 | BHRb | ParE (103) | Unknown | ParD (83) | Unknown | Yes | 72 |
| relBE/pasABC | T. ferrooxidans | PasB (90) | Unknown | PasA (74) | Lon | Yes | 82, 83, 84 |
| stb of pMYSH6000 | S. flexneri | Orf2 (133) | Unknown | Orf1 (75) | Unknown | NDc | 69 |
| hig of Rts1 | BHR | HigB (92) | Unknown | HigA (104) | Unknown | Yes | 90 |
| ɛ/ζ of pSM19035 | BHR | ζ (287) | Unknown | ɛ (90) | Unknown | Yes | 13 |
| relBE of P307 | E. coli | RelE (95) | Translation | RelB (83) | Lon | Yes | 30 |
| relBE/stbDE of R485 | M. morganii | RelE/StbE (93) | Unknown | RelB/StbD (83) | Unknown | Yes | 32 |
| relBE of pJK21 | A. europaeus | RelE (93) | Unknown | RelB (87) | Unknown | ND | This work |
| relBE of pRJF2 | B. fibrisolvens | RelE (93) | Unknown | RelB (83) | Unknown | ND | This work |
| relBE of pB171 | E. coli | RelE (95) | Unknown | RelB (83) | Unknown | ND | This work |
| relBE of p11184 | P. shigelloides | RelE (94) | Unknown | RelB (80) | Unknown | ND | This work |
a
Plasmid R485 is from M. morganii, pMYSH6000 is from Shigella flexneri, pJK21 from Acetobacter europaeus, pasABC is from the T. ferrooxidans plasmid pTF-CF2, ω-ɛ-ζ of pSM19035 is from S. pyogenes, and plasmid pRJF2 is from B. fibrisolvens; all other loci are from E. coli plasmids or broad-host-range plasmids (RK2/RP4, Rts1 and pSM19035). Broad-host-range plasmid RK2/RP4 is from gram-negative bacteria, pSM19035 is from gram-positive bacteria.
b
BHR, broad-host-range plasmid.
c
ND, not determined.