FIG 1.

PmrAB-mediated pmrC/eptA-1 expression and cell surface charge. (a) Schematic diagram of PmrAB-induced pmrC/eptA-1 expression. Mutated PmrB continuously activates PmrA, and the resulting activated PmrA regulator binds to the PmrA-binding site (5′-HTTAAD-N₅-HTTAAD-3′) to promote the transcription of pmrC and eptA-1. (b) Expression levels of pmrC/eptA-1 encoding PEtN transferase were examined in clinical strains and compared with those in the Lab-WT strain under the nontreated, 1/2 MIC PMB-treated, and 1/10 MIC PMB-treated conditions. The expression of the strains was normalized to their respective 16S rRNA expression levels. Data were obtained through three independent biological replicates. (c) Zeta potential of the Lab-WT, PMB^R, and PMB^S strains under the nontreated condition.