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. 2022 Jul 11;10(4):e01068-22. doi: 10.1128/spectrum.01068-22

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Copyright © 2022 Qiao et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 4 — Mutation landscapes of microbiota-associated inflammatory genes in HNSC. (A) The significantly downregulated (blue) and upregulated (red) immune-related genes (based on ImmPort Portal) in cluster 3 compared to cluster 2. (B) Spearman association network of significantly differentially abundant bacteria (circle nodes) and differentially abundant immune genes (square nodes) between clusters 2 and 3. The red and blue edges connecting nodes represent significant positive or negative correlations. Only nodes with significant interactions (P < 0.01, |r| > 0.3) were reported for this network. (C) The gene mutation and expression landscape of significantly downregulated immune-related genes in cluster 3 was analyzed in cBioPortal.