Table 1.
Ranking of Endpoints Found in the Literature by the Expert Panel
| Rank | Item | Mean (SD) Score |
|---|---|---|
| 1 | Clinical cure | 8.5 (2.7) |
| 2 | ACM | 7.0 (2.8) |
| 3 | MV-free days | 6.5 (2.4) |
| 4 | Improvement in oxygenation parameters | 5.8 (2.4) |
| 5 | No. of days before resolution | 5.6 (2.4) |
| 6 | CPIS [9] decrease | 5.2 (2.4) |
| 7 | Microbiological cure | 5.1 (2.4) |
| 8 | Safety | 3.8 (2.4) |
| 9 | PCT decrease | 3.7 (3.1) |
| 10 | Acquisition of antimicrobial resistance | 3.0 (2.3) |
A score from 1 (worst) to 10 (best) was attributed to every criterion by each expert according to his or her preference. Results are given as mean (SD) score obtained by each endpoint.
Abbreviations: ACM, all-cause mortality; CPIS, Clinical Pulmonary Infection Score; MV, mechanical ventilation; PCT, procalcitonin; SD, standard deviation.