Table 2.

Comparison of the Incidence of Individual Severe Clinical Events Between 2-Drug Regimens and 3-Drug Regimens

			Univariable			Multivariablea
Event	Regimen type	N Events	IRR	(95% CI)	P Value	IRR	(95% CI)	P Value
Death	3DR	186	1			1
	2DR	18	0.90	(.55–1.46)	.66	0.69	(.42–1.12)	.13
Non-AIDS–defining cancer	3DR	130	1			1
	2DR	26	1.86	(1.22–2.84)	.004	1.35	(.88–2.09)	.17
Cardiovascular disease	3DR	109	1			1
	2DR	14	1.19	(.68–2.08)	.54	0.80	(.45–1.41)	.44
AIDS, noncancer	3DR	80	1			1
	2DR	11	1.28	(.68–2.40)	.44	1.27	(.67–2.43)	.47

Abbreviations: 2DR, 2-drug regimen; 3DR, 3-drug regimen; CI, confidence interval; IRR, incidence rate ratio.

^aMultivariable model adjusted for age, CD4 cell count at regimen start, smoking status, and number of drugs previously exposed to.