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. 2022 Jun 16;7(14):e158207. doi: 10.1172/jci.insight.158207

Figure 5. IL-6 and CXCL2 restore liver recovery rate in mice with senescent cell elimination.

Figure 5

(A) Experimental scheme of ABT263-treated WT male mice subjected to PHx, followed by injections of vehicle (PBS) or a combination of IL-6 (50 μg/kg/d) and CXCL2 (15 μg/kg/d). (B) The remnant liver recovery rates were assessed 2 days after PHx. Injection of IL-6 and CXCL2 fully restored liver mass recovery to the level of WT mice without ABT263 exposure (ABT263+IL-6+CXCL2, n = 7; ABT263 control, n = 5). Data on mice subjected to PHx treated with vehicle, ABT263+IL-6, and ABT263+CXCL2 were drawn from Figure 1B and Figure 4B. (C) Liver sections of indicated mice were stained with anti-Ki67 antibodies to reveal proliferating cells in all 3 zones, and the numbers of Ki67+ cells were counted (n = 4). Scale bar: 50 μm. Data expressed as mean ± SD. **P < 0.002, ***P < 0.001, Student’s t test.