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Upon plasma membrane breach, extracellular Ca2+ enters the damaged cell. Annexin A6 (A6) binds Ca2+, translocates to the site of membrane injury targeting exposed phospholipids such as PS, and forms a repair cap at the lesion. Extracellular recombinant annexin A6 (rA6) localizes to the repair cap at the site of injury, enhancing repair capacity.
