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. Author manuscript; available in PMC: 2022 Aug 31.
Published in final edited form as: Int J Pediatr Otorhinolaryngol. 2020 Aug 18;138:110311. doi: 10.1016/j.ijporl.2020.110311

Figure 4: Auditory Brainstem Responses for OR-404IT.

Figure 4:

The Mean ABR threshold shifts for Low Dose OR-404IT (0.5 mg ciprofloxacin + 0.2 mg dexamethasone), High Dose OR-404IT (1.5 mg ciprofloxacin + 0.6 mg dexamethasone), Vehicle (2.1 mg inactive excipients), Saline (negative control), and Positive Toxicity Control (10% neomycin). Animals were injected with similar treatment bilaterally into the middle ear space. No statistically significant difference was observed between ears in individual animals. ABR data for both ears was combined. No significant difference was noted with the exception of the toxic control. The threshold shifts were measured at 4 kHz (A), 10 kHz (B) and 20 kHz (C). Pre represents the ABR threshold of animals before implantation and Post represents the ABR threshold prior to euthanasia.