Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Animal were injected bilaterally via the transtympanic route by slow bolus injection as a fixed dose once on Day 1 (75 μL each ear).
| GROUP | Treatment | Dose Level (mg/kg) | NUMBER OF ANIMALS | |||
|---|---|---|---|---|---|---|
| Number | ABR | Cytocochleogram | Otic Histopathology | |||
| M | M | M | M | |||
| 1 | Vehicle | 0 | 7 | 7 | 7 | 7 |
| 2 | Saline | - | 5 | 5 | 5 | 5 |
| 3 | OR-404IT | 0.5 mg ciprofloxacin + 0.2 mg dexamethasone | 8 | 8 | 8 | 8 |
| 4 | OR-404IT | 1.5 mg ciprofloxacin + 0.6 mg dexamethasone | 10 | 10 | 10 | 10 |
| 5 | OR-IT Control | 10% Neomycin | 5 | 5 | 5 | 5 |
