Fig. 2. Exemplary cases of BBB permeability (Ktrans) maps overlayed on coronal T1-weighted images. Compared to the normal control subject, the patient with Alzheimer dementia shows increased Ktrans values in the bilateral medial temporal lobes and other brain regions. Ktrans is a volume transfer constant between blood plasma and the extravascular extracellular space. Cognitive normal subject (left image). Patient with Alzheimer's disease (right image).
BBB = blood–brain barrier