Table 3.

Subgroup analysis of diagnostic effect.

Subgroup	No. studies	No. patients	Sensitivity			Specificity
			value	I2 (%)	p	value	I2 (%)	p
Study type
Cohort	7	2982	0.51(0.47-0.54)	96.8	< 0.001	0.98 (0.98-0.99)	92.7	< 0.001
Case control	2	257	0.85(0.76-0.91)	92.5	< 0.001	1.00 (0.98-1.00)	0.0	1.000
Patients
newborn	8	3102	0.53(0.49-0.56)	96.6	< 0.001	0.98 (0.98-0.99)	91.7	< 0.001
premature	1	137	-	-	-	-	-	-
LUS diagnostic criteria
Only DLP	5	2900	0.47(0.43-0.51)	96.1	< 0.001	0.98 (0.98-0.99)	95.2	< 0.001
DLP& B-lines	4	339	0.98(0.94-1.00)	45.9	0.136	0.99 (0.96-1.00)	11.7	0.335
Gold standard
CXR	2	2968	1.00(0.94-1.00)	0	1.000	0.99 (0.97-1.00)	64.9	0.091
CXR & clinical history	7	271	0.51(0.47-0.54)	96.3	< 0.001	0.98 (0.98-0.99)	92.8	< 0.001