Table 1.
Studies on sarcopenia in pediatric patients with chronic liver disease.
Author/Year | Patients/number/gender | Age | Method of diagnosis | Evaluation | Clinical outcome |
---|---|---|---|---|---|
Mangus 201714 | ESLD/35/ females 60% Age- and sex-matched healthy controls/35. |
Mean 7.8 (range 0•17) yrs. | CT L 2-L3 Psoas muscle area/height. No assessment of muscle function. |
Comparison with matched controls. | 23% sarcopenia in ESLD vs. controls. Female gender: more fat and less muscle. Age 13•17 yrs, higher prevalence of sarcopenia. |
Lurz 201815 | ESLD/23/ females 60% Age- and sex-matched healthy controls/46 |
Mean 0.9 (range 0.5•3.7) yrs. | CT L 3-L4 Psoas muscle area/height. No assessment of muscle function. |
Comparison with matched controls. | Psoas muscle area significantly decreased in ESLD children. |
Mager 201816 | 1•8 yrs Post-liver transplantation/41/ females 58%. |
0.5•17 years | DEXA No assessment of muscle function. |
Skeletal muscle mass z-score < 2. | Sarcopenia in 40% of post liver transplant children. |
ESLD, end-stage liver disease., CT, computed tomography, DEXA, dual-energy X-Ray absorptiometry.